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Scientists at Burnham Institute for Medical Research (Burnham) and the University of California San Diego (UC San Diego) School of Medicine have demonstrated in mice that transplanted pancreatic precursor cells are protected from the immune system when encapsulated in polytetrafluorethylene (PTFE). The study, which suggests a new approach to treating Type 1 diabetes, was published online on April 8 in the journal Transplantation. googletag.cmd.push(function() googletag.display('div-gpt-ad-1450190541376-1'); ); The team of scientists showed that after transplantation, the precursor cells mature into functional beta cells that are glucose-responsive and control blood sugar levels. Additionally, the study demonstrated that using precursor cells, instead of more committed beta cells, enhanced the cell transplant's chances of success.
The investigators used two different mouse models in the study. The team transplanted mouse islet cells into other mice to demonstrate that the cells were protected from the immune system when encapsulated in PTFE. Human cells encased in PTFE were then transplanted into immunodeficient mice to study the viability and function of both mature beta cells and precursor cells inside the device. Itkin-Ansari's team found that by using precursor cells that had not completely differentiated, the transplanted cells could regenerate into fully functional beta cells. This has important implications for how stem cell-derived tissue should be transplanted in the future.
Taralee Nightingale Turner started sleeping in her swimsuit when she was eight, even though the tight Lycra straps cut into her small shoulder blades and hipbones. And as she got older, and her breasts and hips rounded and her legs grew long, she wore more than one suit at night because of the chlorine, that caustic chemical that shaved away at her suit's stomach like the electric razors the boys on her high school team used so close to their scalps. The chlorine bleached her hair and burned her skin, but she hated it the most because it burrowed in the suits. Wearing only one suit was risky because within a few weeks faint edges and shapes could be seen through the thin fabric at practice. 041b061a72